CASCADE-CATALYSED NANOCARRIER DEGRADATION FOR REGULATING METABOLISM HOMEOSTASIS AND ENHANCING DRUG PENETRATION ON BREAST CANCER

Cascade-catalysed nanocarrier degradation for regulating metabolism homeostasis and enhancing drug penetration on breast cancer

Abstract The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy.Herein, an integrated and tumor microenvironment (TME)-responsive nanocarrier is designed, which can dilate vessle and improve the drug penetration by in situ releasing nitric oxide (NO).Briefly, S-nitroso-glutathione (GSNO

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